Technology, platforms and assays

With seven fully equipped sites located around the world, we have the experience, capacity and technical ability to take on your study. Our dedicated analytical teams have extensive experience in interpreting multi-parameter data – generating high-quality data suitable for reporting at the highest level.

Ligand binding assays to investigate biomarkers

We have multiple platform options to perform ligand binding assays, adapting to meet a wide variety of immune-related endpoints. Available in single-plex or multiplex formats across multiple platforms, our ligand binding assays allow for the assessment of soluble biomarkers of immune function across several preclinical models and humans.

• Cytokine assessment for humans, NHP, rats, mice, dogs, and cats in plasma, serum, and other biological matrices
• Total immunoglobulin assessment
• Immunoglobulin isotyping
• Complement assessment
• T-cell dependent antibody responses
• Cytokine production from cytokine release assays
• Custom immunoassay method development
   

Enhanced flow cytometry, customizable to your I&I needs

The wide range of applications for flow cytometry make it one of the most powerful tools in I&I. Our experienced team and state-of-the-art flow cytometers allow us to phenotype immune cells, assess receptor occupancy and build custom assays to measure the effects of your molecule on the immune system.

• Immunophenotyping panels for humans, NHP, rats, mice, dogs, and cats
• Receptor occupancy
• Characterization of cell-based test articles
• Phagocytosis Assays
• Intracellular cytokine productions
• Intracellular protein phosphorylation
• Custom immunophenotyping panels
• Custom flow-based assays
   

Cell-based assays and cell culture capabilities to elucidate the immunology and immunotoxicology of your molecule

Our expertise in immune cell biology and cell culture capabilities will help you make the right decisions to build a clearer understanding of the pharmacological and immunological interactions of your molecule. Supporting your program from early development, all the way to your IND application.

We can work with you to characterize and formulate cell-based test articles or build an assay strategy to help de-risk the development of your large or small molecules. We can support you on all your cell-based work, whether that’s handling and formulating cell-based test articles, developing and validating cell-based assays or conducting standard cell-based assays for assessing preclinical pharmacology.

Underpinning these activities are comprehensive cell culture capabilities with a range of state-of-the-art incubators and a wide array of established cell-lines.

• NK-cell killing assay
• Cell-based test article formulation and characterization
• Cytokine release assays (whole blood, PBMC, HD PBMC, and BOEC formats available)
• Cell proliferation assay
• ELISPOT and fluorospot assay
• Co-culture assays
• Long term cell culture
• Live cell imaging
• CAR-T IL-2 independent growth assay

State-of-the-art facilities staffed by an experienced team

With labs, specialist equipment and expert staff located across seven sites globally, we have the capacity to adapt, starting your study as soon as possible. Recent investments in equipment and facilities means your studies are run by a growing team of experienced immunologists with extensive experience in drug safety testing, who can leverage state-of-the-art equipment as well.